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Paper Details

Paper Title
Development and application of Liquid Chromatographic method for determination of Carvoverine in bulk and in Intramuscular injection dosage forms
Abstract
Carvoverine is an antifungal agent of the novel echinocandin class. Carvoverine, the first inhibitor of fungal b-1,3 glucan synthesis to receive approval by the United States Food and Drug Administration, is effective for the treatment of mucosal and invasive candidiasis and invasive aspergillosis. It is also active in vitro and in animal models against a number of other filamentous and dimorphic endemic fungi and in animal models of Pneumocystis carinii infection. Carvoverine is a water-soluble amphipathic lipopeptide is a semisynthetic derivative of pneumocandin B0, a fermentation product of Glarea lozoyensis. Developing a accurate and precise alytical method for the estimation of cagpsofungin in a sterile, lyophilized product for intravenous (IV) infusion a is very challenging, due to the formation of drug-drug and drug-excipient interactions. The present study demonstrates the applicability of chromatographic method to develop a new, sensitive, single HPLC method for the quantitative determination of antifungal agents in freeze dried powder for injection pharmaceutical dosage form. Chromatographic separation active pharmaceutical ingredient was achieved by using a Gradient elution at a flow rate of 1.0 mL/min on Zorbax Eclipse XDB-C18 (250mm×4.6 mm, 5μm particle size, 100Å pore size) at ambient temperature. The contents of the mobile phase were 3.48 gms of Di Potassium hydrogen ortho-phosphate (0.03M) in 1000 ml of water and by adjusting the pH to 3.2 with dilute ortho-phosphoric acid (mobile phase solvent-A) and Acetonitrile (mobile phase solvent-B) in a Gradient mode in the ratio of 30: 70 (v/v) of separation was used to resolute the Carvoverine. UV detection at 260 nm was employed to monitor the analytes. A linear response was observed for Carvoverine over the concentration range 4-48 μg/ mL. Limit of detection (LOD) and Limit of quantification (LOQ) for Carvoverine were found to be 0.04μg/mL, and 0.12μg/mL respectively.
Keyword
Carvoverine, Gradient-HPLC, Casporan®, Lyophilized powder for injection.
Others Details
Paper Id : 32592
Author Name : Dr.L.Satyanarayana
Co-Author Name(s) : Sumalatha. Reddi
Volume/Issue No : Volume 05 Issue 03
Page No : 112-119
DOI Number : DOI:10.21090/IJAERD.32592
License : This work is licensed under a Creative Commons Attribution 4.0 International License.
website : http://www.ijaerd.com/index.php
Impact Factor : 5.71, SJIF-2017
ISSN Details : eISSN: 2348-4470, pISSN:2348-6406
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